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Monday, March 29, 2010

US FDA Says Eisai, Pfizer Alzheimer Ads Misleading

FDA says TV ads overstate Alzheimer drug's results. Two television commercials for Eisai Co Ltd (4523.T) and Pfizer Inc's (PFE.N) Alzheimer's drug Aricept are misleading because they suggest the therapy offers a drastic improvement not supported by available data, U.S. regulators said in a letter released on Friday.

The Food and Drug Administration, in a letter dated Feb. 3, said the ads depicted patients whose behavior changes dramatically after taking the medication even though results from clinical trials do not support such an improvement.

"The inclusion of the superimposed text, 'Individual results may vary,' does not mitigate these misleading presentations," the FDA added.

The letter is the latest in a series of warnings to drugmakers and other companies about problematic advertisements, warnings that have increased under the Obama administration. Most are resolved between the agency and drugmakers without further incident, but the administration has been moving to make them public more quickly.

Both ads show a parent and their adult child discussing Aricept with a doctor then shifting to scenes with the patient interacting with their families, moving quickly and tackling tasks such as gardening or feeding pets, according to the FDA.

Such a characterization "misleadingly overstates the efficacy of Aricept, implying a greater benefit than has been supported by substantial evidence," the FDA said.

In its letter, the FDA asked Eisai to respond to the agency in writing by Feb. 18.

Eisai, in a statement, said it would weigh the FDA's comments and in the meantime would discontinue the commercials. Pfizer, which co-markets the drug, could not immediately be reached for comment.

Source: http://www.globalaging.org/health/us/2010/usfda.htm

Expert Tips for Treating Older HIV Patients

AIDS-defining conditions and risks are different for HIV-positive patients who are older, usually defined as age 50 and above, experts say.

Older HIV patients often have higher risks of CMV disease, Kaposi sarcoma, oral candidiasis, wasting syndrome, HIV encephalopathy, and AIDS dementia complex..

Also, older patients typically underreport symptoms such as diarrhea, pain, and depression, but will focus on weight loss, hair loss, and peripheral neuropathy.

"We found that patients who are older and have HIV infection have a higher prevalence of hypertension, hypertriglyceridemia, and low bone mineral density, suggestive of osteoporosis and abnormalities in distribution of body fat," says Nur Onen, MBChB, an instructor in internal medicine in the infectious diseases division of Washington University School of Medicine in St. Louis, MO.

"This problem of accelerated bone loss has been defined in younger HIV patients, as well," Onen notes. "Just when antiretroviral therapy (ART) first is started patients' bone density goes down, and then it stabilizes, so we think it's caused predominantly by HIV infection."

The changes in body fat put HIV patients at greater risk of diabetes, she says.
Since HIV physicians also are often their patients' primary care doctors, they should screen patients for clinical depression, which also is common in older patients, Onen suggests.

"We should talk with them about it and have colleagues who are counselors meet with them," she says.

Another issue concerns the compounding of HIV and lifestyle choices, including smoking, substance abuse, and exposure to other viral infections.

"We have to be very aggressive with our older HIV population and tell them to stop smoking and try our best to address any alcohol and substance use issues that may impact their health and their ability to stay on their HIV medications," Onen says. "We should be aggressive in recognizing and treating depression because it also can impact their medication use."

Clinicians also should encourage patients to maintain good diabetic control, when this is an issue, and check for malignancies, she adds.

"We need to keep HIV patients as healthy as possible for as long as possible," she says.


Source: http://www.globalaging.org/health/us/2010/tips.htm

Gay Seniors Come Out Late, Start Second Lifetime

On his 75th birthday, Bill Farthing decided to be reborn. In the six years since he'd buried his wife of 45 years, he'd felt as he did long before: Lonesome, different, outcast. He wondered if he was going crazy; he contemplated suicide.

Looking back, the clues leading to this day had been scattered throughout his life, but only made sense just now.

So Farthing dressed in the most basic of blue wool skirt suits he could find on the Internet, with a white blouse and low-heeled, open-toed white shoes, and went shopping. Arms loaded with skirts and blouses from the clearance rack,
Farthing approached the checkout.

"Did you find everything you wanted, ma'am?" the cashier asked.
Farthing looked over his shoulder, then realized she was talking to him. He had pulled it off.

He had become a she.

This photo taken Thursday, March 11, 2010, shows Chrissie Farthing,  76, posing for a portrait in her home in Oakville, Mo. After the death  of his wife of 45 years, Bill Farthing recently underwent sexual  reassignment surgery and changed her first name to Chrissie.
This photo taken Thursday, March 11, 2010, shows Chrissie Farthing, 76, posing for a portrait in her home in Oakville, Mo. After the death of his wife of 45 years, Bill Farthing recently underwent sexual reassignment surgery and changed her first name to Chrissie. (AP Photo/Jeff Roberson)


Increased awareness and acceptance of varied sexualities and gender identities has led Americans to come out far younger, as early as middle school. A less noticed but parallel shift is happening at the other end of the age spectrum, with people in their 60s, 70s and 80s coming to terms with the truth that they are gay, lesbian, bisexual or transgender.

While no one tracks the numbers of the elderly who come out, those who work with older adults say the trend is undeniable, and a resulting network of support groups and services has cropped up.

The decision can fracture lifelong relationships. Or it can bring the long-sought relief of an unloaded secret.

"For the first time in my life, I'm not putting on a show," said Farthing, who eventually had sexual reassignment surgery and changed her first name to Chrissie. "It seems like I've been out on a cloud all my life and now I'm not. I'm me."

Outing yourself late in life can be complicated after having lived through times when being openly gay could get you arrested, put in an institution and given shock treatments. It's snarled in a lifetime of trudging along through society's view of normalcy and the resulting fear of being ostracized by children and grandchildren. And it's marked by a nagging doubt that all the heartache, all the potential for it to go wrong, may not be worth it with one's years numbered.

"When somebody comes out at the age of 20, they have their whole life ahead of them," said Karen Taylor, the director of training and advocacy for SAGE, a national group that works with LGBT seniors. "There's a real sense of regret and loss for somebody who comes out later in life, even when talking to them and they say the decision was the right one."

Still, many seniors have felt empowered by the growing presence of gays and lesbians in pop culture and some high-profile, late-in-life outings. Among the most notable, "Family Ties" star Meredith Baxter came out in December at 62; Richard Chamberlain, long the target of rumors, came out in 2003 at 69, decades after the height of his career as a TV heartthrob.

Those who've mustered the gumption to out themselves say they feel as if they've been given a second chance.

Carl Martin, 83, of Falls Church, Va., came out as gay not long after his wife died in 1997. He says he was happy in his marriage but had known of his feelings for men since he was in high school and revealed an unrequited crush to a friend. Coming out, he says, has changed him from a withdrawn, tense, reticent bystander to a vibrant social butterfly who even talks to strangers in the supermarket.

"I would describe these as the happiest years of my life," he said. "I'm free to be who I am. I was not free to be who I was before."

The realization often doesn't come easily. Sue Pratt, 74, of Kirkwood, Mo., remembers having feelings for her high school English teacher, but she wasn't sure what to do with them when she always dreamed of getting married and having a husband. She got her wish, but even when her husband left her, she still couldn't come to terms with the truth.

"You would think I would say, 'I'm free now,'" she said. "But that thought never occurred to me. I was so deep in denial."

Eventually, in her 60s, she answered a personal ad and slowly began coming out to her loved ones as a lesbian. Not everyone has taken it well, as she feared would be the case, but she has no regrets.

"I didn't want to have a secret," she said. "It doesn't matter if I lose every friend that I have, this is what I have to do."

Dr. Loren Olson, a psychiatrist in Des Moines, Iowa, who has studied late-in-life outings, said for most such seniors, there are losses, though they are typically less than they fear, and often vary greatly by socioeconomics.

Olson himself was 40 before he came out. While it may seem incomprehensible to some, he said it makes sense that many can't face the truth for so long, even if some around them have surmised it.

"We don't like disharmony in our thinking so sometimes we block out things that really are in opposition to really what we believe is true," he said. "It's like a child believing in Santa Claus: You just hang on to that as long as you can."
------
Farthing's life was sprinkled with hints.

As a boy, his mother asked one day how he liked school. "It was OK," Farthing said. "But it would be better if I was a girl."

He didn't want to do the things other boys did. Girls didn't want him around. He fought every haircut.

"We've got a homo on our hands," he overheard his father say.

But with no sense what to do with his feelings of being different, life wore on.
He served in the Air Force. He lived overseas. And then there was that girl he found at a pub in England.

She felt different, too, always attracted more to women than men. But they got along so well. And they fell in love.

Sex was never a big part of their relationship, but a daughter was born. The marriage, Farthing says, was happy. Both of them thought they would die with their soul mate by their side.

She did. He wasn't so lucky.

Afterward, he tried anything to keep busy. He got his pilot's license back. He bought a small plane; he built a hangar.

One day, he needed a brass, elbow-shaped piece for his plane's fuel line. They call them male-to-female fittings, and he typed some such phrase into his computer. One of the search results that popped up was titled "The Male Lesbian Complex."

"That's stupid," he thought, moving along to find the part.

But later, something drove him back. The description of the "complex" sounded just like him. Was he always meant to be a woman? Was he too old to accept this?

"I read it and it was so close to me that it made the hair stand up on the back of my neck," Farthing said.

The transformation that followed has not sat well with all, of course.
A neighbor runs indoors now when Farthing comes outside of her Oakville, Mo., home. A brother-in-law and other relatives have cut her out of their lives. And her volunteer work at a nursing home had to end when her secret became known.

But those who are closest have accepted her. And now, in life's twilight, she says she finally feels whole, finally feels normal.

"For the first time ever my life feels like it's in the right place," she said. "I'm going to check out of this world the way I was meant to come into it."


Source:http://www.globalaging.org/health/us/2010/GaySeniors.htm

Wednesday, March 24, 2010

Holy Family Dementia Support Group Meet , Mumbai

Holy Family Dementia Support Group, Mumbai meets every last Saturday of the month, in March 2010 we are meeting on Sat 27th.


Holy Family Dementia Support Group is supported by Silver Inning Foundation & ARDSI Greater Mumbai Chapter and works for Dementia & Alzheimer's.



The group is supported by psychiatrist, clinical psychologist, social workers and family members.

Activity for Support Group:

Counseling, Training of family members, Training of professional care givers, Monthly Meeting, Awareness campaign, Sharing, Lectures, Reference Service etc. All services are free. Only therapy if required will be charged.


Contact: Ms.Raheen Jummani - 9029000091 , Email:silverinnings@gmail.com



Date: Sat 27th March 2010


Time: 4.00 pm to 5.00 pm


Venue:

Memory Clinic

CHILD & ADOLESCENT GUIDANCE CENTRE

Holy Family Hospital

ST. ANDREW'S ROAD
BANDRA (WEST)
MUMBAI 400 050
INDIA


Date and Time for future meetings:

Last Saturday of every month at 4pm to 5pm.


For Silver Innings Dementia Support group in association with ARDSI Greater Mumbai Chapter - From Bhayandar to Andheri contact: Tel: 9987104233


PLS Forward it to your group and friends.


Thks.

Tuesday, March 23, 2010

“THE HUMAN RIGHTS OF THE ELDERLY AND THE NEED FOR NETWORKING”

University Grants Commission (UGC) former chairman Arun Nigavekar said the rights, needs and demands of senior citizens need to be recognized in all aspects.

Speaking at a daylong workshop for students on the topic 'Human Rights of the Elderly and the Need for Networking', he said nothing less than a revolution is required where not only the legal framework but also the social, economic and cultural infrastructure must be enhanced to protect and promote their human rights.


The workshop, organized by the International Longevity Centre-India (ILC-I), University of Pune (UoP) and United Nations Population Fund (UNFPA), was held on the varsity campus on Saturday 20th March 2010 at PUMBA Auditorium of Pune University campus,Pune,India.


Nigavekar said there is a need to create enabling strategies to galvanise an open, transparent and vibrant society.


The workshop focused on the rights of elderly and how their rights can be espoused through networking.


Technical sessions covering various topics such as legal and social security provisions for the elderly, health and housing, prevention of elder abuse and crimes against the elderly, feminisation of ageing, economic security and pensions and networking of NGOs among other issues were conducted.

Speakers included eminent persons from the organiser institutions as well as top officials from the police force and activists from various NGOs.


ILC-I's executive director Ravindra Surve stressed on the importance of networking towards the empowerment of senior citizens. "Networking alone can promote human rights," he said, adding that the world has become a global village and it is only through networking that we can know and understand the work done by each other.


Gender-based violence advisor at UNFPA Syed Sadiq said various factors like widowhood, gender discrimination, inadequate educational, health and employment opportunities have made elderly women more vulnerable.


Spreading awareness and proper information is the need of the hour, Sadiq said, while expressing the need for a coordinated approach towards elders where helplines should be started and all services should be made available to them under one roof so that they need not run from pillar to post.


UoP's professor and department of law head TSN Sastry emphasised on the importance of human rights of the elderly and said it is through education that awareness can be spread about the issue.

Sailesh Mishra of Silver Inning Foundation talked about ' Networking of NGOs in the field of Ageing and Human Rights’. He emphasized the need of United Forum of organization working for Elderly to fight for rights of Elderly and also to advocate and lobby for the cause of elderly with government and civil society.

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